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Cyclophosphamide

Mechanism of action

It is converted to an active metabolite which causes DNA crosslinking leading to DNA miscoding, breaks and defective repair of DNA, causing cell death. Cyclophosphamide inhibits both cellular & humoral immunity.

Indication

It is used when a rapid onset of action is needed for example in case of severe ocular inflammation. It is also used in necrotizing Scleritis, Behcet’s disease, Wegener’s granulomatosis, systemic lupus erythematous, refractory intermediate uveitis.

Dosage

Side effects

Haemorrhagic cystitis, Carcinoma urinary bladder, bone marrow suppression, alopecia and sterility.

Monitoring

Complete blood count & routine urine analysis initially weekly at the initiation of therapy and then at least every 4 weeks once the dosage is stable. Cyclophosphamide therapy is discontinued /stopped if WBC count is less than 3000/µL, platelet count is less than 75,000/ µL

Statutory Warning

Materials / Informations provided here are for educational purpose only ; and not to be used for medical advice, diagnosis or treatment