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Cyclosporine

Cyclosporine is not a cytotoxic drug; it is a cytostatic drug, so inflammation may recur when the drug is stopped. For this rebound phenomenon, the drug is generally used for a long time.

Cyclosporine A is derived naturally from a fungus Beauvaria nivea

 

Mechanism of action

It works on T cell by binding to an intracellular peptide know as cyclophylin which results in blockage of transcription and production of interleukins, activation of CD4& CD8 T cells & production of other lymphokines such as interferon. Cyclosporine A is derived naturally from a fungus Beauvaria nivea.

Indication

same as Azathioprine.

Dosage

2-5mg/kg/day in one or two divided doses.

Side effects

Renal toxicity, hypertension, hepatotoxicity, gingival hyperplasia, hypertrichosis

Monitoring

Blood pressure and serum creatinine-initially every week until stable, then every 3-4 weeks.

Statutory Warning

Materials / Informations provided here are for educational purpose only ; and not to be used for medical advice, diagnosis or treatment