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Foscarnet

Unlike most of the antiviral agents, foscarnet is not a purine or pyrimidine analog. Instead, it is a pyrophosphate derivative.

Mode of action

Like other antivirals, foscarnet does not require activation by viral (or human) kinases. It works by reversibly inhibiting viral DNA and RNA polymerases, thereby interfering with viral DNA and RNA synthesis.

Pharmacokinetics:

Anti-viral profile

Foscarnet has broad in vitro antiviral activity. It is approved for CMV retinitis in immunocompromised hosts and for acyclovir-resistant HSV and herpes zoster infections. It has in vitro activity against HSV, VZV, CMV, EBV, HHV-6, KSHV, and HIV-1.

Adverse effects

Adverse effects include nephrotoxicity, anemia, nausea, and fever. Hypocalcemia, hypomagnesemia hypokalemia, hypo- and hyperphosphatemia, seizures, and arrhythmias have been reported. The most significant side effect with foscarnet is renal impairment. It is necessary to monitor the serum creatinine levels and adjust the drug dosage before every injections.

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Statutory Warning

Materials / Informations provided here are for educational purpose only ; and not to be used for medical advice, diagnosis or treatment