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Mycophenolate Mofetil

Mycophenolate Mofetil is derived from the fungus Penicillium stoloniferum

Mechanism of action:  

It inhibits purine metabolism. It inhibits the enzyme inosine monophosphate dehydrogenase, which in turn inhibits the synthesis of guanosine thereby affecting the proliferation of  B & T lymphocytes. Mycophenolate Mofetil is a prodrug which is metabolized in liver and converted to its active form mycophenolic acid.

Indication:

It is mainly used as alternative to Azathioprine. Vogt-Koyanagi-Harada disease, sympathetic ophthalmia, Behcet’s Disease, Wegener’s granulomatosis in remission, chronic iridocyclitis, scleritis, serpiginous choroiditis [13, 14].

Dosage:

1000mg twice a day, available as 250mg & 500mg capsules

Side effects:

Weight loss, gastrointestinal upset and bone marrow suppression. Mycophenolate Mofetil has lower side effects than other antimetabolites because they don’t interfere with the salvage pathway of purine synthesis.

Monitoring:



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