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Valganciclovir


Valganciclovir is the L-valyl ester of ganciclovir. Like valacyclovir, valganciclovir has high oral bioavailability.

Mode of action:  

Same as Ganciclovir.

Pharmacokinetics:

Valganciclovir is well absorbed and rapidly metabolized in the intestinal wall and liver to ganciclovir. The absolute bioavailability of oral valganciclovir is 60% and plasma protein binding is less than 2%. The major route of elimination is renal.
It may be given in therapeutically effective doses for treatment of CMV retinitis. Dosage is 900 mg twice a day for 3 weeks, then 900 mg once daily as maintenance.

Anti-viral profile:

Valganciclovir is indicated for the treatment of CMV retinitis in patients with AIDS and for the prevention of CMV disease in high-risk kidney, heart, and kidney-pancreas transplant patients.

Adverse effects:

Myelosuppression and CNS or liver toxicity are potential side effects.

Resistance:

Same as Ganciclovir.

 

Statutory Warning

Materials / Informations provided here are for educational purpose only ; and not to be used for medical advice, diagnosis or treatment