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Vidarabine


Vidarabine was the second antiviral drug developed for human use.

Mode of action:

It acts by the inhibiting viral DNA synthesis.

Pharmacokinetics:

When used topically, it is absorbed to a greater extent than idoxuridine and can be used topically for herpetic infection, but is often given by injection for this condition. Because vidarabine is relatively insoluble, its topical preparation is not available as eye drop. It is formulated as a 3% ophthalmic ointment. The recommended dosage is five times a day at 3 hour intervals.

Anti-viral profile:

Vidarabine is effective against strains of herpes simplex (I and II), varicella-zoster and vaccinia (DNA viruses). Vidarabine was also the first drug shown to be effective systemically in the treatment of herpetic encephalitis.

Adverse effect:

Corneal epithelial punctate keratopathy, foreign body sensation, lacrimation, conjunctival hyperemia, burning, irritation, pain, photophobia, sensitivity, and punctal occlusion.

Statutory Warning

Materials / Informations provided here are for educational purpose only ; and not to be used for medical advice, diagnosis or treatment