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Acetazolamide | Acetylcholine | Acyclovir | Adalimumab | Amikacin | Amphotericin B | Ampicillin | Apraclonidine| Atropine | Azathioprine | Azelastine | Betaxolol | Bevacizumab| Biologicals | Brimonidine | Brinzolamide  | Bupivacaine | Capsofungin  | Cefazolin | Cidofovir | Ciprofloxacin | Clotrimazole | Corticosteroids | Cyclopentolate | Cyclosporine A | Cyclophosphamide | Daclizumab | Dorzolamide | EDTA | Epinephrine | Etanercept| Erythromycin | Famciclovir | Foscarnet | Fluconazole | Fluorescein Sodium | Fluorometholone | 5-Fluorouracil | Flurbiprofen   | Ganciclovir | Gatifloxacin | Gentamicin | Glycerin | Homatropine | Hydroxypropyl | Idoxurudine | Indocyanine Green | Infliximab | Interferon alpha | Itraconazole | Ketoconazole | Ketorolac | Latanoprost | Leflunomide | Lidocaine | Loteprednol | Mannitol  | Methotrexate | Methylene Blue | Mitomycin | Moxifloxacin | Mycophenolate Mofetil | Naphazoline | Natamycin | Nedocromil Sodium | Neomycin Sulfate | Ofloxacin | Olopatadine | Pegaptanib | Pilocarpine | Timolol | Valacyclovir | Valganciclovir | Vidarabine | Voriconazole

Apraclonidine

It is a relatively selective α2 adrenergic agonist. When installed in the eye it reduces the IOP and has minimal systemic effects.

Mechanism of Action

The mechanism of action is not clearly understood but it is thought to be that β2 receptors stimulation that results in decrease aqueous humor formation.

Dosage

It is available as topical 0.5% ophthalmic solution (5 ml packs) and 1% in a single dose 0.25% pack. Usually dosage is 1 drop before and after laser procedure.

Indications

  1. It is used to control increase of IOP after anterior segment surgery.
  2. Acute raise in IOP.
  3. And now most recently as adjuvant to other antiglaucoma drugs.

Contra indications

It includes hypersensitivity to the drug and also cardiac disease with untreated arteriovenous block or bradycardia.

Adverse Reactions

  1. Upper lid elevation.
  2. Conjunctival blanching.
  3. Burning or itching sensation.
  4. Subconjunctival hemorrhage.

Statutory Warning

Materials / Informations provided here are for educational purpose only ; and not to be used for medical advice, diagnosis or treatment