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Brimonidine Tartrate

It is a recently introduced 2nd generation α-adrenergic receptor agonist, with high degree selective to α2 receptors.It has a dual action. It decreases aqueous humor production like β-blockers and also increases the uveo scleral out flow like prostagladins.It has binding sites in the iris epithelium, ciliary epithelium, ciliary muscle, retina and retinal epithelium and choroid.After administration its peak plasma level is achieved in 2-4 hours, and declines with a systemic half-life period of approximately 3 hours.

Dosage:

It is available in 0.2% solution (5, 10, 15ml Packs). Instill one drop twice daily.

Indications:

Open Angle Glaucomas and OHT.The IOP decreasing ability decreases over a period of time so one must keep this in mind while treating patients.

Contraindications

In hypersensitivity to brimonidine tartrate, in patients receiving MAO inhibitor therapy, it should be used in caution with patients with depression and coronary insufficiency. Caution while using it in pregnant and lactating mothers.
Caution in contact lens users. They have to wait for at least 20 mins before using the lens as it gets absorbed in to the lens.

Adverse effects


• Oral dryness, headache, and ocular hyperemia
• Burning and stinging, blurring or vision
• Foreign body sensation
• Conjunctival follicle formation
• Ocular allergic reactions
• Corneal staining and erosion
• Photophobia
• Abnormal taste
• Depression, hypotension, sedation, anxiety, insomnia
• Palpitation, nasal dryness and syncope.

Statutory Warning

Materials / Informations provided here are for educational purpose only ; and not to be used for medical advice, diagnosis or treatment