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Valacyclovir:


Valacyclovir is the L-valyl ester of acyclovir, which has greater oral bioavailability than acyclovir.

Mode of action:

same as acyclovir

Pharmacokinetics:

Valacyclovir is rapidly hydrolysed to acyclovir after oral administration by intestinal and hepatic first-pass metabolism and achieve serum levels that are three to five times greater than those achieved with oral acyclovir and approximate those achieved with intravenous acyclovir administration. Oral bioavailability is 54%, and cerebrospinal fluid levels are 50% of those in serum. Elimination half-life of the drug is 2.5-3.3 hours.

Anti-viral profile:

The drug is active against herpes simplex virus (HSV) Types 1 and 2, varicella-zoster virus (VZV).   Valacyclovir has also been shown to be effective in preventing cytomegalovirus disease after organ transplantation when compared with placebo.

Side effects:

Valacyclovir is usually well tolerated, although nausea, vomiting, or rash occasionally occur. Agitation, dizziness, headache, liver enzyme elevation, anemia, and neutropenia are rare. At higher doses CNS manifestations like confusion, hallucinations, and seizures have been reported.

Statutory Warning

Materials / Informations provided here are for educational purpose only ; and not to be used for medical advice, diagnosis or treatment